Description

(3β,5Z,7R,8α,22E)-3S-tert-Butyldimethylsilyl-9,10-Secoergosta-5,10(19),22-Triene-7,8-Diol is a key synthetic intermediate in the production of vitamin D analogs and other high-value steroidal compounds. This compound matters for its role as a protected precursor, enabling precise chemical transformations in complex organic synthesis while maintaining stereochemical integrity. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on developing new therapeutic agents, particularly in the fields of endocrinology and oncology.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of calcitriol (active vitamin D3) and its structural analogs for therapeutic use.
• Fine Chemical Synthesis: Used in the production of other secosteroids and hormonally active compounds requiring specific stereochemistry at the 3-position.
• Research & Development: Serves as a building block in medicinal chemistry for exploring new vitamin D receptor (VDR) modulators and related biological pathways.
• Process Chemistry: Employed in scale-up and optimization of manufacturing routes for vitamin D-based active pharmaceutical ingredients (APIs).
• Biochemical Probes: Can be utilized to create labeled or modified sterols for studying metabolic pathways and receptor interactions.

Basic Information

Item	Details
Product Name	(3β,5Z,7R,8α,22E)-3S-tert-Butyldimethylsilyl-9,10-Secoergosta-5,10(19),22-Triene-7,8-Diol
CAS No.	131852-63-6
Molecular Formula	C36H62O2Si
Molecular Weight	554.96 g/mol
Synonyms	3S-TBDMS-9,10-Secoergosta-5,10(19),22-Triene-7,8-Diol; (3S)-3-[(tert-Butyldimethylsilyl)oxy]-9,10-secoergosta-5,10(19),22-triene-7,8-diol; 3β-(tert-Butyldimethylsilyloxy)-9,10-seco-5,10(19),22-cholestatrien-7,8-diol; TBDMS-protected Vitamin D3 intermediate; 3-TBDMS-Provitamin D3; 1α,25-Dihydroxyvitamin D3 synthetic precursor (TBDMS protected); Steroid synthesis intermediate CAS 131852-63-6
EINECS	Contact for details

Quality Control

Our (3β,5Z,7R,8α,22E)-3S-tert-Butyldimethylsilyl-9,10-Secoergosta-5,10(19),22-Triene-7,8-Diol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.