Description

trans-2-(3-Chlorophenyl)Cyclopropanamine Hydrochloride is a high-purity, pharmaceutically relevant chiral amine building block, essential for the synthesis of complex bioactive molecules. Its value lies in the rigid cyclopropane ring and the defined stereochemistry of the trans-isomer, which are critical for modulating biological activity and pharmacokinetic properties in drug discovery. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly for central nervous system (CNS) targets and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including potential antidepressants, anxiolytics, and neuroprotective drugs.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to explore the impact of the cyclopropane scaffold and chlorophenyl moiety on drug potency and selectivity.
• Asymmetric Synthesis: Serves as a valuable starting material or resolving agent in the synthesis of enantiomerically pure compounds due to its defined stereocenter.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and receptor-ligand interactions.
• Agrochemical Research: Investigated as a potential intermediate for developing new crop protection agents with novel modes of action.

Basic Information

Product Name	trans-2-(3-Chlorophenyl)Cyclopropanamine Hydrochloride
CAS No.	131844-46-7
Molecular Formula	C9H11ClN • HCl
Molecular Weight	220.11 g/mol
Synonyms	(1R,2S)-2-(3-Chlorophenyl)cyclopropanamine Hydrochloride; (1S,2R)-2-(3-Chlorophenyl)cyclopropanamine Hydrochloride; trans-2-(3-Chlorophenyl)cyclopropylamine HCl; 2-(3-Chlorophenyl)cyclopropanamine Hydrochloride (trans-); 1-(3-Chlorophenyl)-2-aminocyclopropane Hydrochloride; 3-Chloro-trans-2-phenylcyclopropanamine Hydrochloride; AGN-PC-0E60K5; BCP31933
EINECS	Contact for details

Quality Control

Our trans-2-(3-Chlorophenyl)Cyclopropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (trans-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.