Description

Fmoc-D-Cys(Tbu)-Oh CAS NO 131766-22-8 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled incorporation of D-cysteine into peptide chains while preventing unwanted side reactions during synthesis. This compound is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology industries developing therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled introduction of D-cysteine residues using Fmoc chemistry.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including hormone analogs and antimicrobial peptides.
• Peptidomimetic Design: Serves as a precursor for creating stable, drug-like molecules that mimic natural peptides.
• Chemical Biology & Bioconjugation: Facilitates the site-specific modification of peptides and proteins via the free thiol group after deprotection.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Material Science: Used in the synthesis of peptide-based polymers and biomaterials where controlled chirality and disulfide bonding are required.

Basic Information

Product Name	Fmoc-D-Cys(Tbu)-Oh
CAS No.	131766-22-8
Molecular Formula	C22H25NO5S
Molecular Weight	415.50 g/mol
Synonyms	Fmoc-D-Cys(Trt)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(2-methyl-2-propanyl)thio]-D-alanine; Fmoc-D-Cysteine(Trt)-OH; Fmoc-D-Cys(Trt)-OH; Fmoc-D-Cys(TBU)-OH; Nα-Fmoc-S-tert-butyl-D-cysteine; Fmoc-D-Cys(tBu)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butyl)thio)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Cys(Tbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Optical Rotation	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.