Description

(S)-n-Boc-4-Cyanophenylalanine is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine and a cyano-functionalized aromatic side chain. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control for advanced pharmaceutical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs targeting metabolic diseases, oncology, and CNS disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptidomimetic Synthesis: Used to incorporate a constrained, aromatic, and polar functional group into peptide backbones to enhance metabolic stability and binding affinity.
• PROTAC & Molecular Glue Development: Serves as a versatile linker component in the design of proteolysis-targeting chimeras (PROTACs) and other bifunctional molecules.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and labeled peptides for studying enzyme function and protein-protein interactions.
• Process Chemistry & Scale-up: Suitable for use in route scouting and optimization for the commercial-scale manufacturing of chiral drugs.
• Academic Research: A valuable reagent in university and institutional labs for methodological studies in asymmetric synthesis and peptide chemistry.

Basic Information

Product Name	(S)-n-Boc-4-Cyanophenylalanine
CAS No.	131724-45-3
Molecular Formula	C15H18N2O4
Molecular Weight	290.32 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-cyanophenyl)propanoic acid; Boc-4-Cyano-Phe-OH; Boc-(S)-4-Cyanophenylalanine; N-α-Boc-4-cyano-L-phenylalanine; tert-Butyl (S)-(1-(4-cyanophenyl)-3-carboxy-3-oxopropyl)carbamate; (S)-3-(4-Cyanophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; L-4-Cyanophenylalanine, N-Boc-; BOC-L-4-CYANO-PHE-OH
EINECS	Contact for details

Quality Control

Our (S)-n-Boc-4-Cyanophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.