Description

(2S,3S)-Fmoc-Abu(3-N3)-Oh is a specialized, non-natural amino acid derivative featuring an azide functional group at the β-carbon position, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This unique structure makes it a critical building block for the solid-phase synthesis of peptides and peptidomimetics, enabling the introduction of bioorthogonal handles via click chemistry. It is essential for researchers and manufacturers in pharmaceutical development, chemical biology, and materials science who require precise structural control and functionalization capabilities for advanced drug discovery and bioconjugation projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the controlled assembly of complex peptides, particularly for introducing azide-modified residues.
• Peptidomimetic Drug Discovery: Used to create novel peptide analogs with enhanced stability, bioavailability, or specific biological activity.
• Bioconjugation and Labeling: The azide group enables efficient, site-specific conjugation to alkyne-bearing molecules (via CuAAC or SPAAC click chemistry) for attaching fluorophores, biotin, or other probes.
• Chemical Biology Probes: Serves as a precursor for synthesizing activity-based probes to study enzyme function and protein-protein interactions.
• Materials Science and Polymer Chemistry: Incorporated into functional polymers or hydrogels to create smart materials with tailored chemical reactivity.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the construction of novel linkers and payload attachment sites in targeted cancer therapies.

Basic Information

Item	Details
Product Name	(2S,3S)-Fmoc-Abu(3-N3)-Oh
CAS No.	131669-42-6
Molecular Formula	C20H20N4O4
Molecular Weight	380.40 g/mol
Synonyms	Fmoc-(2S,3S)-3-azido-2-aminobutanoic acid; (2S,3S)-3-Azido-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid; Fmoc-L-Abu(3-N3)-OH; Fmoc-3-azido-L-homoalanine; N-α-Fmoc-3-azido-L-2-aminobutanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azido-L-homoalanine; Fmoc-Azido-homoAla-OH
EINECS	Contact for details

Quality Control

Our (2S,3S)-Fmoc-Abu(3-N3)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below in a desiccated environment. The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.