Description

Fmoc-Arg-Oh Hcl CAS NO 131669-11-9 is a protected amino acid derivative, specifically the Fmoc (9-fluorenylmethoxycarbonyl) derivative of L-arginine hydrochloride. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide-based drug discovery, therapeutic development, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of peptides.
• Pharmaceutical Intermediates: For the research and production of peptide-based active pharmaceutical ingredients (APIs) and therapeutic candidates.
• Bioconjugation & Protein Engineering: Used to introduce arginine residues with orthogonal protection for site-specific modifications.
• Combinatorial Chemistry Libraries: A fundamental component for generating diverse peptide libraries for high-throughput screening.
• Biochemical Research: Synthesis of substrates, inhibitors, and probes for enzymatic studies and signal transduction research.
• Antibiotic & Antimicrobial Peptide Development: For constructing peptides with cationic arginine residues known for membrane interaction.

Basic Information

Product Name	Fmoc-Arg-Oh Hcl
CAS No.	131669-11-9
Molecular Formula	C21H25N5O4 • HCl
Molecular Weight	471.92 g/mol
Synonyms	Fmoc-L-arginine hydrochloride; N-α-Fmoc-L-arginine hydrochloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-arginine hydrochloride; Fmoc-Arg-OH•HCl; Fmoc-Arg(HCl)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-guanidinopentanoic acid hydrochloride; Fmoc-Arg(Pbf)-OH (Note: Pbf is a different protecting group); Fmoc-Arg(Mtr)-OH (Note: Mtr is a different protecting group)
EINECS	Contact for details

Quality Control

Our Fmoc-Arg-Oh Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.