Description

2-(1-Carboxy-3-Methyl-Butyl)-1,3-Dioxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and proprietary drug formulations.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex APIs, especially for candidates targeting neurological and metabolic disorders.
• Protease Inhibitor Research: Serves as a core structural component in the development of novel protease inhibitors for antiviral and anticancer therapies.
• Peptidomimetic Chemistry: Used to create stable, bioavailable peptidomimetics by incorporating its isoindole-1,3-dione (phthalimide) moiety.
• Organic Synthesis Reference Standard: Employed as a high-purity standard in analytical method development and quality control laboratories.
• Bioconjugation Chemistry: Its carboxylic acid groups enable its use as a linker molecule for attaching payloads in antibody-drug conjugate (ADC) research.
• Material Science Research: Investigated as a monomer or additive for creating specialized polymers with unique thermal or optical properties.

Basic Information

Item	Details
Product Name	2-(1-Carboxy-3-Methyl-Butyl)-1,3-Dioxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid
CAS No.	131613-54-2
Molecular Formula	C16H17NO6
Molecular Weight	319.31 g/mol
Synonyms	5-Carboxy-2-(1-carboxy-3-methylbutyl)isoindole-1,3-dione; 2-(1-Carboxy-3-methylbutyl)-1,3-dioxoisoindoline-5-carboxylic acid; (S)-2-(1-Carboxy-3-methylbutyl)isoindole-1,3-dione-5-carboxylic acid; N-(1-Carboxy-3-methylbutyl)-5-carboxyphthalimide; Leucine-derived phthalimide dicarboxylic acid; CAS 131613-54-2; 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-2-(1-carboxy-3-methylbutyl)-1,3-dioxo-
EINECS	Contact for details

Quality Control

Our 2-(1-Carboxy-3-Methyl-Butyl)-1,3-Dioxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) with complete traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.