Description

L-Proline, 4-Methoxy-1-Methyl-, trans- (9Ci) is a high-purity, non-proteinogenic proline derivative characterized by its specific methoxy and methyl substitutions on the pyrrolidine ring. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemistry. It is essential for research and development in the pharmaceutical industry, particularly for the synthesis of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel drug candidates, especially in oncology, neurology, and metabolic disease research.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints and enhance the metabolic stability, bioavailability, and receptor selectivity of peptide-based therapeutics.
• Asymmetric Synthesis: Employed as a chiral auxiliary or catalyst ligand in stereoselective reactions to create enantiomerically pure compounds.
• Agrochemical Research: Serves as a building block for developing new pesticides and herbicides with specific biological activity.
• Biochemical Research: Utilized in enzymatic studies and as a probe to investigate biological pathways involving amino acid metabolism and transport.
• Material Science: Potential monomer or modifier for creating specialized polymers with unique properties.

Basic Information

Item	Detail
Product Name	L-Proline, 4-Methoxy-1-Methyl-, trans- (9Ci)
CAS No.	131559-49-4
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	(2S,4R)-4-Methoxy-1-methylpyrrolidine-2-carboxylic acid; trans-4-Methoxy-1-methyl-L-proline; 4-Methoxy-1-methyl-L-proline; 1-Methyl-4-methoxy-L-proline; (4R)-4-Methoxy-1-methyl-L-proline; L-Proline, 4-methoxy-1-methyl-, (4R)-; 4-Methoxy-N-methyl-L-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Methoxy-1-Methyl-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.