Description

Fmoc-D-Thr(Bzl)-Oh is a protected derivative of the non-proteinogenic amino acid D-threonine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled assembly of complex peptides and peptidomimetics, where the Fmoc (9-fluorenylmethoxycarbonyl) group provides orthogonal protection. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, enantiomerically pure intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a modified amino acid for creating site-specifically labeled peptides for diagnostics or targeted therapies.
• Biochemical Tool Development: Integral for synthesizing peptide substrates, inhibitors, or probes for enzymatic studies and assay development.
• Material Science: A precursor for constructing peptide-based biomaterials and functional surfaces.
• Academic & Contract Research: A standard reagent in university and CRO laboratories for fundamental peptide chemistry and custom synthesis projects.

Basic Information

Product Name	Fmoc-D-Thr(Bzl)-Oh
CAS No.	131545-63-6
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-D-threonine(benzyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-benzyl-D-threonine; Fmoc-D-Thr(OBzl)-OH; (2R,3R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(benzyloxy)butanoic acid; Fmoc-D-Threonine(OBzl)-OH; Fmoc-O-benzyl-D-threonine; N-Fmoc-O-benzyl-D-threonine; D-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, benzyl ether
EINECS	Contact for details

Quality Control

Our Fmoc-D-Thr(Bzl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to industry best practices and can provide material traceable to relevant standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.