Description

Methyl -L-Daunosamine Hydrochloride is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is a critical building block for the production of anthracycline-based chemotherapeutic agents, valued for its defined stereochemistry and consistent quality. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of daunorubicin, doxorubicin, and related anthracycline antibiotics.
• Oncology Drug Development: Used in research and production of chemotherapeutic agents targeting various cancers.
• Fine Chemical Synthesis: Serves as a specialized building block for constructing complex sugar-modified natural product analogs.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and novel drug discovery.
• Process Chemistry: Utilized in route scouting and scale-up optimization for GMP (Good Manufacturing Practice) production of APIs.

Basic Information

Product Name	Methyl -L-Daunosamine Hydrochloride
CAS No.	131528-45-5
Molecular Formula	C7H16ClNO4
Molecular Weight	213.66 g/mol
Synonyms	Methyl L-Daunosaminide Hydrochloride; L-Daunosamine Methyl Glycoside Hydrochloride; (2S,4S,5R,6R)-5-Amino-2,4,6-trideoxy-4-(dimethylamino)-L-lyxo-hexopyranoside Methyl Hydrochloride; Methyl 3-Amino-2,3,6-trideoxy-4-O-methyl-L-lyxo-hexopyranoside Hydrochloride; Daunosamine Methyl Glycoside HCl; 4-Dimethylamino-2,3,4,6-tetradeoxy-L-lyxo-hexopyranoside Methyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl -L-Daunosamine Hydrochloride is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical intermediate applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to industry best practices and can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.