Description

(E)-3-Hydroxy Doxepin is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant doxepin. This compound is of significant importance for research and development in neuropharmacology and for the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, impurity profiling, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of doxepin and related tricyclic compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and activity of doxepin.
• Impurity Profiling: Serves as a known impurity standard to ensure the purity and safety of doxepin-based drug products.
• Biochemical Research: Tool compound for investigating the mechanisms of action of tricyclic antidepressants at receptor sites.
• Custom Synthesis: Starting material for the preparation of novel derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(E)-3-Hydroxy Doxepin
CAS No.	131523-97-2
Molecular Formula	C19H21NO2
Molecular Weight	295.38 g/mol
Synonyms	(E)-3-Hydroxydoxepin; (E)-Doxepin Metabolite; trans-3-Hydroxydoxepin; 3-(E)-Hydroxydoxepin; 1-Propanamine, 3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, (E)-, 3-hydroxy-; Doxepin Hydroxy Metabolite; Doxepin Impurity; NSC 339768
EINECS	Contact for details

Quality Control

Our (E)-3-Hydroxy Doxepin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.