Description

4-(Carboxymethylthio)Dexamethasone is a chemically modified derivative of the potent glucocorticoid dexamethasone, designed to introduce a carboxymethylthio functional group for enhanced solubility and targeted reactivity. This modification is critical for advanced pharmaceutical research, particularly in the development of prodrugs, targeted drug delivery systems, and novel anti-inflammatory agents. It serves as a key synthetic intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors seeking to innovate in corticosteroid-based therapies.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel dexamethasone prodrugs and conjugates.
• Drug Discovery & Development: Used in medicinal chemistry research to create new chemical entities with modified pharmacokinetic profiles.
• Bioconjugation: The carboxylic acid group enables covalent attachment to peptides, proteins, or other targeting molecules for site-specific delivery.
• Anti-inflammatory Research: Serves as a precursor for developing new steroid-based compounds with potential therapeutic applications.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study glucocorticoid receptor pathways and mechanisms.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for specialized steroid derivatives.

Basic Information

Product Name	4-(Carboxymethylthio)Dexamethasone
CAS No.	131467-45-3
Molecular Formula	C25H33FO7S
Molecular Weight	496.59 g/mol
Synonyms	4-(Carboxymethylthio)dexamethasone; Dexamethasone 4-(carboxymethylthio) derivative; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 4-(carboxymethylthio); 4-(Carboxymethylmercapto)dexamethasone; Dexamethasone-4-carboxymethyl thioether; 4-S-(Carboxymethyl)dexamethasone; 4-(Carboxymethylsulfanyl)dexamethasone
EINECS	Contact for details

Quality Control

Our 4-(Carboxymethylthio)Dexamethasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for research and development use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.