Description

2-Amino-3-(3-Trifluoromethyl-Phenyl)-Propionic Acid Methyl Ester is a specialized fluorinated amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, enhancing their lipophilicity and bioavailability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental stability.
• Peptidomimetics Research: Employed in the design and synthesis of peptide analogs and peptidomimetics for biochemical and pharmacological studies.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Potential monomer or additive in the development of specialty polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and pathways.

Basic Information

Product Name	2-Amino-3-(3-Trifluoromethyl-Phenyl)-Propionic Acid Methyl Ester
CAS No.	131235-51-3
Molecular Formula	C11H12F3NO2
Molecular Weight	247.21 g/mol
Synonyms	Methyl 2-Amino-3-[3-(trifluoromethyl)phenyl]propanoate; (R/S)-2-Amino-3-(3-trifluoromethylphenyl)propionic acid methyl ester; 3-(3-Trifluoromethylphenyl)alanine methyl ester; α-Amino-β-(3-trifluoromethylphenyl)propionic acid methyl ester; Methyl 3-(3-trifluoromethylphenyl)alaninate; DL-2-Amino-3-(3-trifluoromethylphenyl)propanoic acid methyl ester; Methyl 2-amino-3-(α,α,α-trifluoro-m-tolyl)propionate
EINECS	Contact for details

Quality Control

Our production of 2-Amino-3-(3-Trifluoromethyl-Phenyl)-Propionic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (if applicable), and specific tests is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.