Description

(R)-A,A-Bis(3-Chlorophenyl)-2-Pyrrolidinemethanol Hydrochloride CAS NO 131180-59-1 is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its role as a critical building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Neurological Research: Used in the research and development of compounds targeting neurological pathways and receptors.
• Asymmetric Synthesis: Employed as a building block in stereoselective chemical reactions to create enantiomerically pure products.
• Process Chemistry: Utilized in route scouting, optimization, and scale-up activities within pharmaceutical process development.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	(R)-A,A-Bis(3-Chlorophenyl)-2-Pyrrolidinemethanol Hydrochloride
CAS No.	131180-59-1
Molecular Formula	C17H18Cl3NO
Molecular Weight	358.69 g/mol
Synonyms	(R)-α,α-Bis(3-chlorophenyl)-2-pyrrolidinemethanol hydrochloride; (R)-3,3'-Dichloro-Benhydrol Hydrochloride; (R)-Bis(3-chlorophenyl)(pyrrolidin-2-yl)methanol hydrochloride; (2R)-α,α-Bis(3-chlorophenyl)-1-pyrrolidinemethanol hydrochloride; (R)-Bis(3-chlorophenyl)(2-pyrrolidinyl)methanol hydrochloride; (R)-CPPM HCl; (R)-enantiomer of A,A-Bis(3-Chlorophenyl)-2-Pyrrolidinemethanol HCl
EINECS	Contact for details

Quality Control

Our (R)-A,A-Bis(3-Chlorophenyl)-2-Pyrrolidinemethanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.