Description

(S)-Alpha,α-Bis(4-Fluorophenyl)-2-Pyrrolidinemethanol CAS NO 131180-45-5 is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for the development of enantiomerically pure pharmaceuticals and fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery and development programs for creating novel therapeutic candidates.
• Agrochemical Synthesis: Employed in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances that demand high enantiomeric purity.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Product Name	(S)-Alpha,α-Bis(4-Fluorophenyl)-2-Pyrrolidinemethanol
CAS No.	131180-45-5
Molecular Formula	C17H17F2NO
Molecular Weight	289.32 g/mol
Synonyms	(S)-α,α-Bis(4-Fluorophenyl)-2-pyrrolidinemethanol; (S)-2-Pyrrolidinemethanol, α,α-bis(4-fluorophenyl)-; (S)-α,α-Bis(p-fluorophenyl)-2-pyrrolidinemethanol; (S)-Bis(4-fluorophenyl)(2-pyrrolidinyl)methanol; (S)-Bis(4-fluorophenyl)(pyrrolidin-2-yl)methanol; (S)-2-[(4-Fluorophenyl)(hydroxy)methyl]-1-(4-fluorophenyl)pyrrolidine; (S)-Enantiomer of α,α-Bis(4-fluorophenyl)-2-pyrrolidinemethanol
EINECS	Contact for details

Quality Control

Our (S)-Alpha,α-Bis(4-Fluorophenyl)-2-Pyrrolidinemethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.