Description

L-Proline, 1-(Chlorocarbonyl)- (9Ci) is a high-purity, protected amino acid derivative, specifically a proline-based N-carboxy anhydride (NCA). This compound serves as a critical building block in the synthesis of complex peptides and peptidomimetics, enabling precise control over molecular architecture. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for advanced drug discovery and development programs. The product is supplied under stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key precursor in the solid-phase and solution-phase synthesis of therapeutic peptides and constrained peptidomimetics.
• Drug Discovery Research: Used in medicinal chemistry for constructing proline-rich scaffolds to explore new biological targets and structure-activity relationships (SAR).
• Bioconjugation: Employed as a reactive handle for labeling peptides or attaching functional groups in bioconjugate and probe development.
• Polymer Chemistry: Acts as a monomer for the ring-opening polymerization (ROP) to create biodegradable poly(amino acid) materials and functional polymers.
• Chemical Biology: Utilized in the synthesis of custom peptides for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Intermediate in the development of novel peptide-based crop protection agents and bioactive compounds.

Basic Information

Product Name	L-Proline, 1-(Chlorocarbonyl)- (9Ci)
CAS No.	131180-40-0
Molecular Formula	C6H8ClNO3
Molecular Weight	177.59 g/mol
Synonyms	L-Proline N-Carboxy Anhydride; L-Proline NCA; (S)-1-(Chlorocarbonyl)pyrrolidine-2-carboxylic Acid; NCA-L-Proline; Proline N-Carboxyanhydride; 1-Chlorocarbonyl-L-proline; L-Pyroglutamic Acid N-Carboxy Anhydride (related); 2-Pyrrolidinecarboxylic acid, 1-(chlorocarbonyl)-, (S)-
EINECS	Contact for details

Quality Control

Our L-Proline, 1-(Chlorocarbonyl)- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications are designed to meet the high standards of pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon). Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in common anhydrous organic solvents (e.g., THF, DMF, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.