Description

(2R,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid CAS NO 131176-02-8 is a high-purity, non-natural amino acid derivative featuring a fluorinated pyrrolidine scaffold. This compound is a critical chiral building block in modern pharmaceutical research, enabling the synthesis of complex molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of novel therapeutics, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor programs.
• Peptidomimetics: Used to construct fluorinated peptide analogs to improve pharmacokinetic properties such as bioavailability and resistance to enzymatic degradation.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation: The carboxylic acid functionality allows for coupling reactions to create labeled probes or antibody-drug conjugates (ADCs).
• Chemical Biology: Employed in the design of enzyme inhibitors and molecular probes to study biological pathways.
• Asymmetric Synthesis: Used as a chiral auxiliary or starting material in stereoselective synthetic routes.

Basic Information

Product Name	(2R,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid
CAS No.	131176-02-8
Molecular Formula	C5H8FNO2
Molecular Weight	133.12 g/mol
Synonyms	(2R,4S)-4-Fluoroproline; (2R,4S)-4-Fluoro-L-proline; 4-Fluoro-(2R,4S)-proline; 4-Fluoro-D-proline (trans); (2R,4S)-4-Fluoropyrrolidine-2-carboxylic acid; L-4-Fluoroproline (2R,4S); trans-4-Fluoro-L-proline; 4-Fluoro-(2R,4S)-pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (2R,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.