Description

Methyl n-Boc-2-piperidineacetate is a high-purity, protected amino acid ester derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile and stable intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API synthesis and novel compound libraries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of piperidine-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetics Research: Used in the design and construction of peptide analogs and constrained scaffolds to modulate biological activity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Medicinal Chemistry: Integral for structure-activity relationship (SAR) studies and the development of novel therapeutic agents targeting CNS, oncology, and other disease areas.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up processes under cGMP or ISO standards.
• Agrochemical Development: Used in the research phase for creating novel crop protection agents and pesticides.

Basic Information

Product Name	Methyl n-Boc-2-piperidineacetate
CAS No.	131134-77-5
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-2-piperidineacetic acid methyl ester; Methyl 2-[(tert-butoxycarbonyl)amino]-2-piperidineacetate; Methyl 2-(Boc-amino)-2-piperidineacetate; Methyl 2-(N-Boc-amino)-2-piperidineacetate; Methyl 2-piperidineacetate, N-Boc-protected; Boc-2-piperidineglycine methyl ester; (2-Piperidinyl)acetic acid, N-Boc-, methyl ester; tert-Butyl 2-(methoxycarbonylmethyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl n-Boc-2-piperidineacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to meet the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is stable under these conditions but should be kept away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.