Description

5,7-Dichlorokynurenic Acid Sodium Salt is a high-purity, research-grade chemical compound of significant interest in neuroscience and pharmacology. This compound serves as a potent and selective antagonist of the glycine site on the NMDA receptor complex, making it a critical tool for studying excitatory neurotransmission and neuroprotective pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and contract research organizations (CROs) engaged in the development of novel therapeutics for neurological disorders.

Application

• Neuroscience Research: A key pharmacological tool for investigating the role of NMDA receptors in synaptic plasticity, learning, memory, and excitotoxicity.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and in vitro assays to identify and characterize new neuroprotective agents or modulators of glutamatergic signaling.
• Mechanistic Studies: Employed to elucidate pathways involved in stroke, traumatic brain injury, epilepsy, and chronic neurodegenerative conditions like Alzheimer's and Parkinson's disease.
• Biochemical Assays: Serves as a standard or reference compound in receptor binding studies and functional assays to validate experimental models.
• Academic & Institutional Research: Supports fundamental research in university and government laboratories focused on central nervous system (CNS) function and dysfunction.

Basic Information

Product Name	5,7-Dichlorokynurenic Acid Sodium Salt
CAS No.	131123-76-7
Molecular Formula	C10H3Cl2NNaO3
Molecular Weight	286.04 g/mol
Synonyms	5,7-Dichloro-4-hydroxyquinoline-2-carboxylic Acid Sodium Salt; DNQX Sodium Salt (common abbreviation); 5,7-Dichlorokynurenate Sodium; Sodium 5,7-Dichloro-4-hydroxyquinaldate; Glycine/NMDA Receptor Antagonist; NMDA Receptor Glycine Site Antagonist
EINECS	Contact for details

Quality Control

Our 5,7-Dichlorokynurenic Acid Sodium Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Heavy Metals	<20 ppm
Residue on Ignition	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.