Description

(2S)-2-Amino-3-[4-(Trifluoromethoxy)Phenyl]Propanoic Acid is a non-natural, fluorinated aromatic amino acid derivative of significant interest in advanced chemical synthesis. Its core value lies in the unique combination of a chiral amino acid backbone with a trifluoromethoxy-substituted aromatic ring, offering enhanced metabolic stability, lipophilicity, and electronic properties to target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel bioactive compounds, including peptide-based therapeutics, enzyme inhibitors, and molecular probes.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of peptide mimetics and small molecule drugs targeting CNS disorders, inflammation, and metabolic diseases.
• Protease Inhibitor Development: Used to incorporate fluorinated motifs into peptide sequences to enhance binding affinity and stability against enzymatic degradation.
• Chemical Biology & Proteomics: Serves as a specialty amino acid for constructing activity-based probes (ABPs) and affinity tags to study enzyme function and protein-protein interactions.
• Agrochemical Research: Employed in the design of novel herbicides and pesticides, where the trifluoromethoxy group can improve bioavailability and environmental persistence.
• Material Science: Potential monomer for synthesizing specialized polymers and coatings with unique surface properties and chemical resistance.
• Academic & Contract Research: A valuable reagent for methodological studies in asymmetric synthesis and fluorine chemistry.

Basic Information

Item	Details
Product Name	(2S)-2-Amino-3-[4-(Trifluoromethoxy)Phenyl]Propanoic Acid
CAS No.	131123-44-9
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	(S)-2-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid; L-4-(Trifluoromethoxy)phenylalanine; (S)-4-(Trifluoromethoxy)phenylalanine; F3CO-Phe-OH; 4-(Trifluoromethoxy)-L-phenylalanine; (S)-α-Amino-4-(trifluoromethoxy)benzenepropanoic acid; 2S-Amino-3-[4-(Trifluoromethoxy)Phenyl]Propionic Acid
EINECS	Contact for details

Quality Control

Our production of (2S)-2-Amino-3-[4-(Trifluoromethoxy)Phenyl]Propanoic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials undergo comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.