Description

L-Proline, 4-(Hydroxymethyl)- (9Ci) is a non-proteinogenic, hydroxylated derivative of the amino acid L-proline, serving as a versatile chiral building block and intermediate in advanced organic synthesis. This compound is valued for its ability to introduce structural complexity and specific stereochemistry into target molecules, which is critical for modulating biological activity and physicochemical properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other enzyme-targeted drugs.
• Peptidomimetics & Drug Design: Used to construct constrained peptide analogs and scaffolds that enhance metabolic stability and receptor selectivity in medicinal chemistry programs.
• Bioconjugation & Linker Chemistry: Serves as a functionalized spacer or linker molecule for attaching payloads in antibody-drug conjugates (ADCs) and other bioconjugates.
• Catalyst & Ligand Synthesis: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to probe the function of proline-hydroxylating enzymes and related biological pathways.
• Fine Chemical Synthesis: Acts as a precursor for the synthesis of complex natural product analogs and other high-value specialty chemicals.

Basic Information

Product Name	L-Proline, 4-(Hydroxymethyl)- (9Ci)
CAS No.	131103-95-2
Molecular Formula	C₆H₁₁NO₃
Molecular Weight	145.16 g/mol
Synonyms	4-(Hydroxymethyl)-L-proline; (2S,4S)-4-(Hydroxymethyl)pyrrolidine-2-carboxylic acid; L-4-Hydroxymethylproline; trans-4-Hydroxymethyl-L-proline; 4-Hydroxymethyl-L-proline; (4S)-4-(Hydroxymethyl)-L-proline; 4-(Hydroxymethyl)-(S)-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 4-(Hydroxymethyl)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for research and pharmaceutical development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.