Description

Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-(Acetylamino)-, (1R-Endo)- (9Ci) CAS NO 131102-03-9 is a high-purity, chiral bicyclic compound featuring a carboxylic acid and an acetamido functional group. This molecule is a critical chiral building block and synthetic intermediate valued for its rigid, three-dimensional structure, which is essential for imparting specific stereochemistry and biological activity in advanced pharmaceuticals. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), asymmetric synthesis, and complex organic molecule construction.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapeutics.
• Asymmetric Catalysis & Synthesis: Used as a ligand precursor or a chiral scaffold in the development of catalysts for enantioselective reactions.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical entities due to its constrained geometry.
• Peptidomimetics & Bioisosteres: The bicyclic framework is utilized to design conformationally restricted analogs of peptides, enhancing metabolic stability and receptor selectivity.
• Advanced Material Science: Acts as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides.

Basic Information

Product Name	Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-(Acetylamino)-, (1R-Endo)- (9Ci)
CAS No.	131102-03-9
Molecular Formula	C10H13NO3
Molecular Weight	195.22 g/mol
Synonyms	(1R-endo)-2-(Acetylamino)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid; 2-Acetamidobicyclo[2.2.1]hept-5-ene-2-carboxylic acid, (1R-endo)-; endo-2-Acetamido-2-norbornene-5-carboxylic acid; (1R,2R,4S)-2-Acetamidobicyclo[2.2.1]hept-5-ene-2-carboxylic acid; Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-(acetylamino)-, (1R,2R,4S)-; N-Acetyl-2-norbornene-2-carboxylic acid (endo isomer); A chiral norbornene derivative.
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylic Acid, 2-(Acetylamino)-, (1R-Endo)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.