Description

Melphalan-n-4-Hydroxyphenoxyacetamide is a chemically modified derivative of the alkylating agent melphalan, designed for targeted research and development applications. This compound is of significant interest for its potential role in creating prodrugs or antibody-drug conjugates (ADCs) aimed at improving therapeutic efficacy and reducing systemic toxicity. It serves as a critical intermediate for pharmaceutical researchers and developers working in oncology, particularly in the synthesis of novel chemotherapeutic agents and targeted delivery systems.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel melphalan prodrugs for cancer therapy.
• Antibody-Drug Conjugate (ADC) Payload Research: Used in the development of targeted cancer therapies where the drug is linked to a monoclonal antibody.
• Oncology Research & Development: Serves as a precursor for experimental compounds in preclinical studies investigating new alkylating agents.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to modify the pharmacokinetic and pharmacodynamic properties of melphalan analogs.
• Bioconjugation Studies: Employed in research focused on linking cytotoxic agents to various carriers, including peptides and polymers.

Basic Information

Product Name	Melphalan-n-4-Hydroxyphenoxyacetamide
CAS No.	131089-09-3
Molecular Formula	C20H23ClN2O5
Molecular Weight	406.86 g/mol
Synonyms	4-Hydroxyphenoxyacetamide Melphalan Derivative; L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, N-(4-hydroxyphenoxy)acetyl-; Melphalan Hydroxyphenoxyacetamide; N-(4-Hydroxyphenoxy)acetylmelphalan; ADC Payload Intermediate; Melphalan Prodrug Intermediate; Alkylating Agent Derivative
EINECS	Contact for details

Quality Control

Our Melphalan-n-4-Hydroxyphenoxyacetamide is manufactured under strict quality systems to ensure high purity and consistency for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for advanced pharmaceutical intermediates, ensuring reliable performance in critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.