Description

n-Acetyl o-Benzyl 5’Epi Lamivudine is a key pharmaceutical intermediate, specifically a protected derivative of the nucleoside analog lamivudine. This compound is critical for enabling advanced synthetic routes in the production of high-purity active pharmaceutical ingredients (APIs) and for research into novel antiviral therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, process development chemists, and manufacturers specializing in nucleoside-based antiviral drugs.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of lamivudine and its structural analogs.
• Antiviral Drug Research: Used in medicinal chemistry for the development and structure-activity relationship (SAR) studies of new nucleoside reverse transcriptase inhibitors (NRTIs).
• Process Chemistry: Serves as a protected precursor in scalable API manufacturing processes, allowing for selective reactions at other sites of the molecule.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in studies investigating the mechanism of action and resistance profiles of antiviral compounds.

Basic Information

Product Name	n-Acetyl o-Benzyl 5’Epi Lamivudine
CAS No.	131086-33-4
Molecular Formula	C15H19N3O4S
Molecular Weight	337.40 g/mol
Synonyms	5'-Epi-Lamivudine 3',5'-Di-O-acetyl Derivative; 1-((2R,5S)-5-(Acetyloxymethyl)-2-((benzyloxy)methyl)-1,3-oxathiolan-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5'-Epi-BCH-189 3',5'-Di-O-acetate; Lamivudine 5'-epimer, N-Acetyl, O-benzyl derivative; 2',3'-Dideoxy-3'-thiacytidine 5'-epimer protected intermediate; BCH-189 5'-epi intermediate; NSC 675186
EINECS	Contact for details

Quality Control

Our n-Acetyl o-Benzyl 5’Epi Lamivudine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.