Description

2-Amino-1,9-Dihydro-9-(2-Fluoro-4-Hydroxy-3-(Hydroxymethyl)Cyclopentyl)-6H-Purin-6-One is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel antiviral and anticancer therapeutics, particularly within the nucleoside analog class. It is essential for pharmaceutical R&D laboratories and manufacturers engaged in the synthesis of next-generation antiviral agents, offering a critical building block for complex molecular architectures.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of novel antiviral nucleoside analogs.
• Antiviral Drug Development: Key precursor for research and production of experimental drugs targeting viral polymerases.
• Oncology Research: Investigated as an intermediate for potential anticancer prodrugs and targeted therapies.
• Biochemical Research: Used in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Chemistry & Scale-Up: Serves as a starting material for process optimization and commercial-scale API (Active Pharmaceutical Ingredient) manufacturing.
• Custom Synthesis: Foundation for the custom synthesis of fluorinated purine derivatives with modified biological activity.

Basic Information

Product Name	2-Amino-1,9-Dihydro-9-(2-Fluoro-4-Hydroxy-3-(Hydroxymethyl)Cyclopentyl)-6H-Purin-6-One
CAS No.	131043-40-8
Molecular Formula	C11H14FN5O3
Molecular Weight	283.26 g/mol
Synonyms	9-[(1S,2S,3S,5R)-3-Fluoro-2-hydroxy-4-(hydroxymethyl)cyclopentyl]guanine; 2-Amino-9-[(1S,2S,3S,5R)-3-fluoro-2-hydroxy-4-(hydroxymethyl)cyclopentyl]-1,9-dihydro-6H-purin-6-one; (1S,2S,3S,5R)-2-Amino-9-(3-fluoro-2-hydroxy-4-(hydroxymethyl)cyclopentyl)-1,9-dihydro-6H-purin-6-one; Fluorinated Cyclopentyl Guanine Analog; Acyclic Nucleoside Phosphonate Precursor; 131043-40-8; FC-guanine derivative
EINECS	Contact for details

Quality Control

Our 2-Amino-1,9-Dihydro-9-(2-Fluoro-4-Hydroxy-3-(Hydroxymethyl)Cyclopentyl)-6H-Purin-6-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are available upon request. Production can adhere to cGMP guidelines for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.