Description

Dehydro Lacidipine is a key pharmaceutical intermediate and impurity standard used in the synthesis and quality control of the active pharmaceutical ingredient (API) Lacidipine. This compound is of critical importance for ensuring the purity, safety, and efficacy of final drug formulations, particularly calcium channel blockers used to treat hypertension. It is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories involved in cardiovascular drug development and regulatory compliance.

Application

• Primary use as a reference standard for the identification and quantification of related substances in Lacidipine API.
• Critical pharmaceutical intermediate in the synthesis and process development of Lacidipine.
• Essential for analytical method development and validation (HPLC, LC-MS) in quality control laboratories.
• Used in stability studies and impurity profiling to meet ICH guidelines.
• Valuable research chemical for studying the metabolism and degradation pathways of dihydropyridine-class drugs.
• Serves as a starting material or building block for the research and synthesis of novel dihydropyridine derivatives.

Basic Information

Product Name	Dehydro Lacidipine
CAS No.	130996-24-6
Molecular Formula	C26H33NO6
Molecular Weight	455.55 g/mol
Synonyms	Lacidipine Impurity; Lacidipine Related Compound; 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-[2-(tert-Butoxycarbonyl)ethyl] 5-Methyl Ester; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-[2-[(1,1-Dimethylethoxy)carbonyl]ethyl] 5-Methyl Ester; Dehydro Lacidipine Impurity; Lacidipine Dehydro Impurity; (E)-Lacidipine
EINECS	Contact for details

Quality Control

Our Dehydro Lacidipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, related substance profiling, and identity confirmation (IR, NMR) to ensure it meets stringent standards for use as a reference material. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with ICH, USP, and EP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.