Description

3',5'-Tips-5-Me-Uridine is a modified nucleoside analog of significant interest in advanced biochemical research and pharmaceutical development. Its primary value lies in its role as a key building block for the synthesis of oligonucleotides with enhanced stability and specific biological activity. This compound is essential for researchers and manufacturers in the fields of antisense therapy, diagnostic probe development, and novel therapeutic agent discovery. The product is supplied under stringent quality controls to ensure consistency and reliability for critical applications.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of modified RNA and DNA strands.
• Antisense & siRNA Research: Used to incorporate modifications that enhance nuclease resistance and target affinity in therapeutic oligonucleotides.
• Diagnostic Probe Development: Serves as a component in the creation of high-specificity probes for genetic testing and molecular diagnostics.
• Medicinal Chemistry: Employed as an intermediate in the research and development of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Tool Development: Utilized in studying RNA structure, function, and protein-RNA interactions.
• Academic & Institutional Research: A key reagent for fundamental studies in molecular biology, genetics, and chemical biology.

Basic Information

Product Name	3',5'-Tips-5-Me-Uridine
CAS No.	130983-87-8
Molecular Formula	C23H34N2O7Si2
Molecular Weight	506.70 g/mol
Synonyms	5-Methyluridine, 2',3'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl); 5-Methyl-2',3'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine; 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-5-methyluridine; TIPS-5-Me-Uridine; 1-((2R,3R,4R,5R)-3,4-Bis((triisopropylsilyl)oxy)-5-((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-2',3'-O-TIPS uridine
EINECS	Contact for details

Quality Control

Our 3',5'-Tips-5-Me-Uridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and conformity to specified standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay purity and impurity profiles. We adhere to cGMP principles where applicable to support its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.