Description

Ethanone, 2,2,2-Trifluoro-1-(2-Phenylcyclopropyl)-, (1R-Trans)- (9Ci) CAS NO 130980-00-6 is a high-purity, chiral trifluoromethyl ketone building block characterized by its unique cyclopropane and phenyl substituents. This compound is of significant value in advanced organic synthesis, particularly for introducing the trifluoroacetyl group with precise stereochemical control. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced, bioactive molecules for crop protection agents, leveraging the stability imparted by the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of novel fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized as a building block for creating activity-based probes and other tools to study enzyme function and biological pathways.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-(2-Phenylcyclopropyl)-, (1R-Trans)- (9Ci)
CAS No.	130980-00-6
Molecular Formula	C11H9F3O
Molecular Weight	214.18 g/mol
Synonyms	(1R,2R)-2,2,2-Trifluoro-1-(2-phenylcyclopropyl)ethanone; (1R-trans)-2,2,2-Trifluoro-1-(2-phenylcyclopropyl)ethanone; 2,2,2-Trifluoro-1-[(1R,2R)-2-phenylcyclopropyl]ethan-1-one; 1-(2-Phenylcyclopropyl)-2,2,2-trifluoroethanone, (1R,2R)-; trans-2,2,2-Trifluoro-1-(2-phenylcyclopropyl)ethanone; (1R,2R)-1-(2-Phenylcyclopropyl)-2,2,2-trifluoroethanone
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-(2-Phenylcyclopropyl)-, (1R-Trans)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure consistent high quality and enantiomeric excess suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep container tightly sealed under an inert atmosphere when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.