Description

m-Peg6-Ms is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a methanesulfonate (Ms) group at one terminus and a methoxy group at the other. This compound is a critical intermediate for the synthesis of complex molecules, enabling precise conjugation and functionalization in advanced research and development. It is primarily utilized by scientists and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors for creating targeted drug delivery systems, diagnostic agents, and novel biomaterials.

Application

• Pharmaceutical Linker Chemistry: Acts as a versatile spacer and linker for attaching drug molecules, targeting ligands, or imaging agents to nanoparticles, antibodies, or other biological carriers.
• Bioconjugation: Used to modify peptides, proteins, and oligonucleotides, improving their solubility, stability, and pharmacokinetic properties.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key building block in the synthesis of cleavable or non-cleavable linkers for ADCs, a leading class of targeted cancer therapeutics.
• Polymer Chemistry: Employed as a functional initiator or monomer in the synthesis of tailored PEG-based block copolymers and hydrogels.
• Surface Functionalization: Used to PEGylate surfaces of medical devices, sensors, and diagnostic platforms to impart anti-fouling properties and enable further bio-functionalization.
• Prodrug Synthesis: Facilitates the creation of prodrugs where the active pharmaceutical ingredient is released upon specific biological triggers.

Basic Information

Product Name	m-Peg6-Ms
CAS No.	130955-38-3
Molecular Formula	C15H32O9S
Molecular Weight	388.48 g/mol
Synonyms	Methoxy-PEG6-mesylate; Methoxy-PEG6-methanesulfonate; mPEG6-OMs; α-Methoxy-ω-methanesulfonyl-pentaethylene glycol; 2,5,8,11,14,17-Hexaoxanonadecan-19-yl methanesulfonate; PEG6 monomethyl ether mesylate; mPEG6-OSO2CH3; (Ethylene glycol)6 monomethyl ether methanesulfonate
EINECS	Contact for details

Quality Control

Our m-Peg6-Ms is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your GMP-compliant and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.