Description

m-Peg5-Ms CAS NO 130955-37-2 is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a methanesulfonate (mesylate, Ms) reactive group at one terminus and a methoxy group at the other. This bifunctional linker is a critical reagent for introducing hydrophilic PEG spacers of defined length into target molecules, enhancing solubility and modifying pharmacokinetic properties. It is primarily utilized by researchers and process chemists in the pharmaceutical, bioconjugation, and advanced materials sectors for the controlled synthesis of antibody-drug conjugates (ADCs), peptide modifications, and polymer therapeutics.

Application

• Bioconjugation & ADC Development: Serves as a key hydrophilic linker for constructing antibody-drug conjugates (ADCs), improving water solubility and reducing aggregation of payloads.
• Peptide & Protein Modification: Used to site-specifically PEGylate peptides, proteins, and enzymes to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Polymer Therapeutics & Prodrugs: Acts as a functionalized building block for synthesizing advanced drug delivery systems, polymer-drug conjugates, and stimuli-responsive materials.
• Crosslinking & Surface Functionalization: Employed to introduce PEG chains onto surfaces, nanoparticles, or solid supports to create non-fouling, biocompatible coatings.
• Organic Synthesis Intermediate: The reactive mesylate group allows for further nucleophilic substitution reactions, making it a versatile intermediate for custom synthesis.
• Diagnostic Reagent Formulation: Used in the development of contrast agents and diagnostic probes where controlled hydrophilicity is required.

Basic Information

Product Name	m-Peg5-Ms
CAS No.	130955-37-2
Molecular Formula	C13H28O8S
Molecular Weight	344.42 g/mol
Synonyms	mPEG5-Ms; Methoxy-PEG5-mesylate; 2,5,8,11,14-Pentaoxaheptadecan-17-yl methanesulfonate; mPEG(5)-OMs; Monomethoxy PEG5 mesylate; PEG Methyl Ether Mesylate (n=5); 1-Methoxy-3,6,9,12-tetraoxapentadec-14-yl methanesulfonate; m-PEG5-OMs
EINECS	Contact for details

Quality Control

Our m-Peg5-Ms is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support cGMP manufacturing for pharmaceutical applications and can supply material compliant with ICH guidelines for stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.