Description

3'-Amino-5'-o-tert-Butyldimethylsilyl-3'-Deoxythymidine is a key nucleoside derivative and a protected intermediate in organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity building blocks for oligonucleotide and prodrug development. It is primarily utilized in the pharmaceutical and biotechnology sectors for the synthesis of novel antiviral agents, modified DNA probes, and other therapeutic nucleosides.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used for the preparation of modified DNA/RNA strands with specific functionalities for research and diagnostics.
• Prodrug Development: Serves as a protected precursor in the design of prodrugs to enhance bioavailability and targeting.
• Biochemical Research: Employed in studies investigating nucleotide metabolism, enzyme mechanisms, and nucleic acid chemistry.
• Antisense Therapy Development: A component in the creation of modified antisense oligonucleotides for therapeutic applications.
• Labeled Nucleotide Production: Acts as a starting material for synthesizing nucleosides tagged with fluorescent or radioactive markers.

Basic Information

Product Name	3'-Amino-5'-o-tert-Butyldimethylsilyl-3'-Deoxythymidine
CAS No.	130945-04-9
Molecular Formula	C16H29N3O5Si
Molecular Weight	371.51 g/mol
Synonyms	3'-Amino-5'-O-(tert-butyldimethylsilyl)-3'-deoxythymidine; 3'-Amino-5'-O-TBDMS-3'-deoxythymidine; 5'-O-(tert-Butyldimethylsilyl)-3'-amino-3'-deoxythymidine; 3'-Amino-3'-deoxy-5'-O-(tert-butyldimethylsilyl)thymidine; TBDMS-protected 3'-amino-3'-deoxythymidine; 3'-NH2-5'-O-TBDMS-dT; 3'-Amino-5'-O-(1,1-dimethylethyl)dimethylsilyl-3'-deoxythymidine
EINECS	Contact for details

Quality Control

Our 3'-Amino-5'-o-tert-Butyldimethylsilyl-3'-Deoxythymidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.