Description

D-2-Trifluoromethylphenylalanine is a non-natural, fluorinated amino acid derivative of significant interest in advanced pharmaceutical and agrochemical research. Its core value lies in the unique properties imparted by the trifluoromethyl group, which can dramatically enhance metabolic stability, lipophilicity, and bioavailability in lead compounds. This high-purity chiral building block is essential for medicinal chemists and process development scientists working on novel peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug discovery programs.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorine moiety can improve activity and environmental stability.
• Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships (SAR) and to create analogs with enhanced biological properties.
• Biochemical Tool: Serves as a substrate or inhibitor in enzymatic studies to probe active site mechanisms and selectivity.
• Material Science: Potential monomer for specialty polymers where fluorine content is desired for specific surface or thermal characteristics.
• Diagnostic Agent Development: Utilized in the design of radiolabeled probes or contrast agents for medical imaging applications.

Basic Information

Product Name	D-2-Trifluoromethylphenylalanine
CAS No.	130930-49-3
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	(R)-2-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid; D-α-Amino-2-(trifluoromethyl)benzenepropanoic acid; (R)-2-Trifluoromethylphenylalanine; D-2-(Trifluoromethyl)phenylalanine; (R)-3-(2-Trifluoromethylphenyl)alanine; D-TfmPhe; (2R)-2-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid; D-2-CF3-Phe
EINECS	Contact for details

Quality Control

Our D-2-Trifluoromethylphenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess (typically ≥99%), and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the original container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.