Description

Ethyl (S)-1-Cbz-4-Hydroxy-2-Pyrrolidinecarboxylate is a high-purity chiral building block and protected amino acid derivative essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the production of complex active pharmaceutical ingredients (APIs) and bioactive molecules, particularly those targeting neurological and metabolic disorders. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, including protease inhibitors and other peptidomimetic drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Development: Used in the research and production of inhibitors for enzymes like dipeptidyl peptidase-4 (DPP-4) and prolyl oligopeptidase.
• Peptidomimetics & Constrained Peptides: Serves as a backbone component for designing and synthesizing peptide analogs with enhanced stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective chemical reactions to introduce the (S)-configured pyrrolidine scaffold.
• Medicinal Chemistry Research: Utilized in lead optimization and structure-activity relationship (SAR) studies for new therapeutic agents.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	Ethyl (S)-1-Cbz-4-Hydroxy-2-Pyrrolidinecarboxylate
CAS No.	130930-28-8
Molecular Formula	C15H19NO5
Molecular Weight	293.32 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]-4-hydroxy-2-pyrrolidinecarboxylic Acid Ethyl Ester; Ethyl (4S)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-prolinate; (S)-1-Cbz-4-Hydroxypyrrolidine-2-carboxylic Acid Ethyl Ester; (S)-4-Hydroxy-1-Cbz-proline Ethyl Ester; (S)-1-(Benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic Acid Ethyl Ester; trans-4-Hydroxy-L-proline Derivative (Cbz-protected, ethyl ester); CBZ-HYP-OET
EINECS	Contact for details

Quality Control

Our Ethyl (S)-1-Cbz-4-Hydroxy-2-Pyrrolidinecarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.