Description

Z-D-cis-Hyp-Oh CAS NO 130930-25-5 is a protected, non-proteinogenic amino acid derivative, specifically the Z-protected form of cis-4-hydroxy-D-proline. This compound matters as a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of peptide-based pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery, peptide synthesis, and as a precursor for complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide drugs and protease inhibitors.
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs, influencing secondary structure.
• Bioconjugation & Probe Development: Serves as a building block for creating labeled peptides or affinity probes for biochemical studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to modulate the pharmacokinetic properties of lead compounds.
• Catalyst & Ligand Synthesis: A precursor for synthesizing chiral catalysts or ligands used in asymmetric synthesis.
• Academic & Industrial R&D: Fundamental research tool in organic chemistry and chemical biology for exploring new synthetic methodologies.

Basic Information

Product Name	Z-D-cis-Hyp-Oh
CAS No.	130930-25-5
Molecular Formula	C₁₃H₁₅NO₅
Molecular Weight	265.26 g/mol
Synonyms	N-Carbobenzoxy-cis-4-hydroxy-D-proline; Z-cis-4-Hydroxy-D-proline; (2S,4R)-1-[(Benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid; N-Cbz-cis-4-hydroxy-D-proline; (4R)-N-[(Benzyloxy)carbonyl]-4-hydroxy-D-proline; N-Z-cis-4-hydroxy-D-proline; Benzyl (2S,4R)-4-hydroxy-2-carboxypyrrolidine-1-carboxylate; D-cis-4-Hydroxyproline, N-benzyloxycarbonyl-
EINECS	Contact for details

Quality Control

Our Z-D-cis-Hyp-Oh is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and optical rotation analysis, to ensure high chemical and chiral purity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.