Description

Bis(L-Valine) Ester Ganciclovir Tfa Salt is a chemically modified prodrug derivative of the antiviral nucleoside analogue ganciclovir. This compound is specifically engineered to enhance bioavailability and targeted delivery, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and research institutions focused on developing next-generation antiviral therapies, particularly for cytomegalovirus (CMV) and other herpesviruses.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the production of advanced antiviral prodrug formulations.
• Antiviral Drug Development: Used in research for improving the pharmacokinetic profile, oral absorption, and tissue targeting of ganciclovir-based therapies.
• Prodrug Research: A model compound for studying amino acid ester prodrug strategies to enhance membrane permeability and drug delivery.
• Bioconjugation & Labeling Studies: Employed in chemical biology for attaching antiviral agents to targeting moieties or diagnostic labels.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Bis(L-Valine) Ester Ganciclovir Tfa Salt
CAS No.	130914-71-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ganciclovir Divalinate Trifluoroacetate; Ganciclovir Bis(L-Valine) Ester TFA Salt; 9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine Bis(L-Valinate) Trifluoroacetate; GCV Divalinate Ester TFA; 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl 2-amino-3-methylbutanoate (ester) trifluoroacetate (salt); L-Valine, ester with 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine, trifluoroacetate (salt); Ganciclovir Valine Ester TFA
EINECS	Contact for details

Quality Control

Our Bis(L-Valine) Ester Ganciclovir Tfa Salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings (e.g., FDA DMF, CEP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.