Description

2'-o-(tert-Butyldimethylsilyl)-3'-Deoxy-5'-o-Trityluridine is a key protected nucleoside intermediate, specifically designed for advanced oligonucleotide synthesis and pharmaceutical research. This compound is critical for the controlled synthesis of modified RNA and DNA sequences, where precise protection and deprotection strategies are required. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA therapeutics, and other nucleic acid-based drugs.

Application

• Oligonucleotide Synthesis: Serves as a crucial building block for the solid-phase synthesis of modified RNA and DNA strands, particularly where 3'-deoxy modifications are desired.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) designed to target specific mRNA sequences.
• siRNA and miRNA Therapeutics: Acts as a protected intermediate in the synthesis of small interfering RNA (siRNA) and microRNA (miRNA) analogs for gene silencing applications.
• Pharmaceutical Intermediates: A vital precursor in the multi-step synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Chemical Biology Research: Employed in academic and industrial labs to study nucleic acid structure, function, and to create probes for diagnostic assays.
• Process Development: Used in scaling up and optimizing manufacturing processes for GMP-grade active pharmaceutical ingredients (APIs) in the nucleic acid therapeutics sector.

Basic Information

Product Name	2'-o-(tert-Butyldimethylsilyl)-3'-Deoxy-5'-o-Trityluridine
CAS No.	130860-12-7
Molecular Formula	C39H48N2O6Si
Molecular Weight	668.90 g/mol
Synonyms	2'-O-TBDMS-3'-deoxy-5'-O-trityluridine; 3'-Deoxy-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-trityluridine; 2'-O-(tert-Butyldimethylsilyl)-3'-deoxy-5'-O-trityluridine; 2'-TBDMS-3'-deoxy-5'-Tr-uridine; 3'-dU(TBDMS,Tr); Uridine, 3'-deoxy-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-triphenylmethyl-
EINECS	Contact for details

Quality Control

Our 2'-o-(tert-Butyldimethylsilyl)-3'-Deoxy-5'-o-Trityluridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided, and we can support custom synthesis to meet specific purity or packaging requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.