Description

α-Me-Phe(3-F)-Oh is a fluorinated, non-natural amino acid derivative, specifically an α-methylated phenylalanine analog with a fluorine substituent at the 3-position of the aromatic ring. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds where enhanced metabolic stability and specific receptor binding are required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of peptide mimetics and protease inhibitors.
• Peptidomimetics Design: Incorporation into peptide backbones to modulate conformation, bioavailability, and resistance to enzymatic degradation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and α-methylation on biological activity.
• Chemical Biology Probes: Serves as a building block for fluorescent or affinity tags to study protein-protein interactions.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral molecules.
• Agrochemical Research: Potential intermediate in the synthesis of novel active ingredients with optimized properties.

Basic Information

Product Name	α-Me-Phe(3-F)-Oh
CAS No.	130855-56-0
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	(S)-2-Amino-3-(3-fluorophenyl)-2-methylpropanoic acid; (S)-α-Methyl-3-fluorophenylalanine; (S)-3-Fluoro-α-methylphenylalanine; L-α-Me-3-F-Phe-OH; (2S)-2-Amino-2-methyl-3-(3-fluorophenyl)propanoic acid; 3-Fluoro-L-α-methylphenylalanine; Fmoc-α-Me-Phe(3-F)-OH (precursor form)
EINECS	Contact for details

Quality Control

Every batch of α-Me-Phe(3-F)-Oh is produced under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality system supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.