Description

2,4-Bis-tert-Butoxycarbonylamino-Butyric Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block for the controlled introduction of a diamino butyric acid moiety, enabling the creation of complex peptide and peptidomimetic structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and targeted drug conjugates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to construct non-natural peptide analogs with enhanced metabolic stability and bioavailability for drug discovery programs.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors targeting specific enzymatic pathways.
• Linker Chemistry: Employed in the synthesis of bioconjugates and antibody-drug conjugates (ADCs) due to its bifunctional, protected amine groups.
• Solid-Phase Peptide Synthesis (SPPS): A valuable Boc-protected building block for the sequential assembly of complex peptides.
• Chemical Biology Probes: Used to create labeled or modified peptides for studying protein-protein interactions and cellular processes.

Basic Information

Product Name	2,4-Bis-tert-Butoxycarbonylamino-Butyric Acid
CAS No.	130853-32-6
Molecular Formula	C₁₄H₂₆N₂O₆
Molecular Weight	318.37 g/mol
Synonyms	2,4-Bis[(tert-butoxy)carbonylamino]butanoic acid; (2,4-Bis-((tert-butoxycarbonyl)amino)butyric acid; Boc-Dab(Boc)-OH; (S)-2,4-Bis((tert-butoxycarbonyl)amino)butyric acid; 2,4-Di-Boc-amino butyric acid; L-2,4-Diaminobutyric acid di-Boc derivative; H-Dab(Boc)₂-OH; N²,N⁴-Bis(tert-butoxycarbonyl)-2,4-diaminobutanoic acid
EINECS	Contact for details

Quality Control

Our 2,4-Bis-tert-Butoxycarbonylamino-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.