Description

4,4-Difluoroglutamic Acid is a high-value, fluorinated derivative of the amino acid glutamic acid, distinguished by the strategic introduction of fluorine atoms at the 4-position. This modification significantly alters its physicochemical and metabolic properties, making it a critical building block in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for the synthesis of novel bioactive compounds. The compound is supplied under strict quality control to ensure batch-to-batch consistency for sensitive applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in oncology and neurology, where fluorine incorporation can enhance metabolic stability and bioavailability.
• Protease Inhibitor Research: Used in the design and synthesis of inhibitors for glutamate-processing enzymes, relevant for therapeutic target validation.
• Agrochemical Synthesis: Serves as a precursor for novel fluorinated pesticides and herbicides, leveraging fluorine's ability to improve lipophilicity and environmental persistence.
• Biochemical Tool Compound: Employed in metabolic pathway studies to investigate the role of glutamic acid analogs in biological systems.
• Peptidomimetics Development: Incorporated into peptide backbones to create analogs with enhanced resistance to enzymatic degradation for diagnostic and therapeutic applications.
• Material Science Research: Potential monomer for synthesizing specialized fluorinated polymers with unique surface properties.

Basic Information

Product Name	4,4-Difluoroglutamic Acid
CAS No.	130835-20-0
Molecular Formula	C5H7F2NO4
Molecular Weight	183.11 g/mol
Synonyms	DL-4,4-Difluoroglutamic Acid; (2R,4R)- and (2S,4S)-4,4-Difluoroglutamic Acid; 4,4-Difluoro-DL-glutamic Acid; Glutamic acid, 4,4-difluoro-; 2-Aminopentanedioic acid, 4,4-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 4,4-Difluoroglutamic Acid is manufactured and analyzed under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting customer and research standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.