Description

(2S,4S)-1-(Benzyloxycarbonyl)Pyrrolidine-2,4-Dicarboxylic Acid is a high-purity, chiral pyrrolidine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected diacid intermediate for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of peptidomimetics, protease inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting proteases and other enzymes.
• Peptidomimetic Scaffold: Used to construct constrained peptide analogs and macrocyclic compounds for drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in metal-catalyzed transformations.
• Bioconjugation Chemistry: The carboxylic acid groups provide handles for coupling to biomolecules or solid supports.
• Academic and R&D: Utilized in medicinal chemistry research for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	(2S,4S)-1-(Benzyloxycarbonyl)Pyrrolidine-2,4-Dicarboxylic Acid
CAS No.	130830-73-8
Molecular Formula	C15H17NO6
Molecular Weight	307.30 g/mol
Synonyms	1-CBZ-(2S,4S)-2,4-Pyrrolidinedicarboxylic Acid; (2S,4S)-1-[(Benzyloxy)carbonyl]-2,4-pyrrolidinedicarboxylic Acid; (2S,4S)-1-(Cbz)-2,4-Pyrrolidinedicarboxylic Acid; 1-Cbz-trans-4-hydroxy-L-proline derivative; Z-(2S,4S)-2,4-Pyrrolidinedicarboxylic Acid; (S,S)-1-(Benzyloxycarbonyl)pyrrolidine-2,4-dicarboxylic acid; (2S,4S)-2,4-Pyrrolidinedicarboxylic acid, 1-[(phenylmethoxy)carbonyl]-; CAS 130830-73-8
EINECS	Contact for details

Quality Control

Our (2S,4S)-1-(Benzyloxycarbonyl)Pyrrolidine-2,4-Dicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data for chiral purity, assay, and related substances. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.