Description

5-Oxo-L-Pro-1-Cbz-L-His-L-Pro-Nh2 is a synthetic, protected tripeptide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial building block (intermediate) for the synthesis of more complex peptides and peptidomimetics, enabling the exploration of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) focused on drug discovery, particularly in areas requiring specific histidine and proline motifs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel peptide-based therapeutics.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of targeted bioactive compounds.
• Peptide Synthesis: Serves as a protected fragment in solid-phase or solution-phase peptide synthesis (SPPS) for constructing longer peptide chains.
• Biochemical Research: Employed as a tool compound in enzymatic studies and proteomics research due to its specific amino acid sequence.
• API Development: Acts as an intermediate in the developmental pathway of potential Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	5-Oxo-L-Pro-1-Cbz-L-His-L-Pro-Nh2
CAS No.	130818-00-7
Molecular Formula	C24H30N6O6
Molecular Weight	498.54 g/mol
Synonyms	5-Oxo-L-prolyl-Nα-carbobenzoxy-L-histidyl-L-prolinamide; Nα-[(Benzyloxy)carbonyl]-L-histidyl-L-prolinamide 5-oxo-L-proline; Cbz-His-Pro-NH2 5-Oxo-Pro; L-Histidine, Nα-[(phenylmethoxy)carbonyl]-, 1-[2-[[(2S)-5-oxo-2-pyrrolidinyl]carbonyl]amino]-1-(L-prolylamino)ethyl]-; Protected His-Pro Dipeptide Amide; Z-His-Pro-NH2 (5-Oxo-Pro); CBZ-HIS-PRO-NH2 (5-OXO-PRO)
EINECS	Contact for details

Quality Control

Our 5-Oxo-L-Pro-1-Cbz-L-His-L-Pro-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.