Description

Cbz-D-Tryptophan Methyl Ester is a protected amino acid derivative of significant importance in synthetic organic and medicinal chemistry. This chiral building block is essential for the controlled synthesis of peptides and peptidomimetics, offering a versatile handle for further chemical elaboration. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for developing novel therapeutic agents and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of the D-tryptophan residue with orthogonal protection.
• Bioconjugation & Probe Development: Serves as a precursor for fluorescent probes or affinity labels due to the intrinsic fluorescence and reactivity of the indole side chain after deprotection.
• Chemical Biology Research: Employed in studying enzyme-substrate interactions, receptor binding, and the structure-activity relationships (SAR) of bioactive peptides.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the asymmetric synthesis of complex natural products and non-natural amino acids.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals, reference standards, and high-value compounds for various industrial applications.

Basic Information

Product Name	Cbz-D-Tryptophan Methyl Ester
CAS No.	130812-44-1
Molecular Formula	C20H20N2O4
Molecular Weight	352.39 g/mol
Synonyms	N-Carbobenzoxy-D-tryptophan methyl ester; (R)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoate; D-Tryptophan, N-[(phenylmethoxy)carbonyl]-, methyl ester; Z-D-Trp-OMe; CBZ-D-TRP-OME; Benzyloxycarbonyl-D-tryptophan methyl ester; Methyl N-carbobenzyloxy-D-tryptophanate
EINECS	Contact for details

Quality Control

Our Cbz-D-Tryptophan Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.