Description

α-Methyl-L-2-Fluorophe CAS NO 130780-36-8 is a high-purity, non-natural fluorinated amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in enabling the precise introduction of a fluorine atom and a methyl group into complex molecular architectures, which is essential for modulating the biological activity and metabolic stability of target compounds. This product is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly peptidomimetics and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially in oncology and central nervous system (CNS) disorders.
• Peptidomimetic Design: Used to incorporate fluorinated, non-proteinogenic amino acids into peptide backbones to enhance stability, bioavailability, and receptor binding affinity.
• Agrochemical Research: Serves as a building block for developing new, more effective pesticides and herbicides with improved environmental profiles.
• Proteomics & Biochemical Research: Employed in the study of enzyme mechanisms and protein-protein interactions where fluorine acts as a spectroscopic or mechanistic probe.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring fluorinated components for specific thermal or chemical resistance properties.

Basic Information

Product Name	α-Methyl-L-2-Fluorophe
CAS No.	130780-36-8
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	(S)-2-Amino-3-(2-fluorophenyl)-2-methylpropanoic acid; L-α-Methyl-2-fluorophenylalanine; (2S)-2-Amino-3-(2-fluorophenyl)-2-methylpropanoic acid; FMOC-α-Me-2-F-Phe-OH (protected form); 2-Fluoro-α-methyl-L-phenylalanine; NSC 760463; α-Methyl-2-fluoro-L-phenylalanine; Non-natural fluorinated amino acid
EINECS	Contact for details

Quality Control

Our α-Methyl-L-2-Fluorophe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and specific tests are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.