Description

Methyl 4-(1,3-Dioxoisoindolin-2-Yl)-2-Hydroxybutanoate is a specialized organic compound featuring a phthalimide-protected amine moiety and a hydroxy ester functional group, making it a versatile chiral building block for complex synthesis. This compound matters for its role as a key intermediate in the development of high-value pharmaceuticals and fine chemicals, where precise molecular architecture is critical. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and neurological disorder research.
• Peptidomimetic Synthesis: Used to incorporate non-natural amino acid analogs into peptide chains to enhance stability and bioactivity.
• Agrochemical Development: Serves as a building block for creating advanced herbicides and fungicides with specific chiral activity.
• Protecting Group Chemistry: The phthalimide group acts as a robust amine protecting group in multi-step organic syntheses.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API route development and scale-up projects.

Basic Information

Product Name	Methyl 4-(1,3-Dioxoisoindolin-2-Yl)-2-Hydroxybutanoate
CAS No.	130695-36-2
Molecular Formula	C13H13NO5
Molecular Weight	263.25 g/mol
Synonyms	2-Hydroxy-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoic acid methyl ester; Methyl 2-hydroxy-4-(phthalimido)butyrate; 4-Phthalimidobutanoic acid, 2-hydroxy-, methyl ester; Methyl 4-phthalimido-2-hydroxybutyrate; 2-Hydroxy-4-phthalimidobutyric acid methyl ester; (R/S)-Methyl 4-(1,3-dioxoisoindolin-2-yl)-2-hydroxybutanoate
EINECS	Contact for details

Quality Control

Our Methyl 4-(1,3-Dioxoisoindolin-2-Yl)-2-Hydroxybutanoate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with stringent industry standards for research and development use. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.