Description

2',3'-Didehydro-2',3'-Dideoxy-5'-Acetate Inosine is a chemically modified nucleoside derivative, serving as a critical intermediate in advanced pharmaceutical synthesis and biochemical research. Its value lies in its role as a versatile building block for the development of antiviral and anticancer nucleotide analogs, enabling precise molecular modifications. This compound is essential for research institutions and pharmaceutical manufacturers focused on nucleoside chemistry, prodrug development, and the synthesis of novel therapeutic agents targeting viral infections and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and polymerase function.
• Prodrug Development: Serves as a modified scaffold for creating prodrugs with enhanced bioavailability and targeted delivery.
• Antiviral Agent Synthesis: Critical for the research and development of novel analogs active against a range of DNA and RNA viruses.
• Oncology Research: Investigated for the development of chemotherapeutic agents that interfere with cancer cell DNA/RNA synthesis.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical labs.

Basic Information

Product Name	2',3'-Didehydro-2',3'-Dideoxy-5'-Acetate Inosine
CAS No.	130676-57-2
Molecular Formula	C12H12N4O5
Molecular Weight	292.25 g/mol
Synonyms	5'-O-Acetyl-2',3'-didehydro-2',3'-dideoxyinosine; 2',3'-Dideoxy-2',3'-didehydroinosine 5'-acetate; ddIno-5'-Acetate; D4I 5'-Acetate; 9-[(1S,4R,5R)-4-Acetoxy-2-cyclopenten-1-yl]-9H-purin-6-ol; 2',3'-Unsaturated-2',3'-dideoxyinosine 5'-acetate
EINECS	Contact for details

Quality Control

Our 2',3'-Didehydro-2',3'-Dideoxy-5'-Acetate Inosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided to ensure compliance with research and cGMP starting material guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.