Description

Fmoc-D-Allo-Thr-Oh CAS NO 130674-54-3 is a protected, non-proteinogenic amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the D-allo-threonine residue into peptide chains, enabling the creation of complex, stereochemically defined peptides with enhanced stability and biological activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies developing novel therapeutic peptides, peptide hormones, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of custom peptide sequences.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including antimicrobial peptides (AMPs) and metabolic hormone analogs.
• Bioconjugation & Labeling: Used to incorporate specific amino acid motifs into peptides for subsequent conjugation with dyes, tags, or drug molecules.
• Chemical Biology & Proteomics: Tool for studying protein-protein interactions and enzyme specificity by incorporating non-standard amino acids.
• Peptide Library Construction: Essential for creating diverse combinatorial peptide libraries for high-throughput screening.
• Academic & Industrial R&D: Fundamental reagent for exploratory research in medicinal chemistry and structural biology.

Basic Information

Product Name	Fmoc-D-Allo-Thr-Oh
CAS No.	130674-54-3
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-D-allo-threonine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-allo-threonine; (2R,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxybutanoic acid; D-allo-Threonine, N-Fmoc derivative; Fmoc-D-aThr-OH; Fmoc-D-allo-Thr; N-Fmoc-D-allo-threonine; Fmoc-D-allothreonine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Allo-Thr-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.5%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.