Description

3-o-(tert-Butyldimethylsilyloxy)-6-o-Desmethyl Buprenorphine is a key pharmaceutical intermediate and a protected derivative of buprenorphine. This compound is critical for researchers and manufacturers engaged in the synthesis of advanced opioid analgesics and for studying metabolic pathways. It is primarily utilized in pharmaceutical R&D, analytical reference standard preparation, and process chemistry for the development of controlled-release formulations and novel therapeutic agents targeting pain management.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of buprenorphine and its analogs.
• Analytical Reference Standard: Used in HPLC, LC-MS, and GC-MS methods for the quantification and purity assessment of buprenorphine and related substances in drug substances and products.
• Metabolic Studies: Serves as a standard or precursor in investigating the metabolism and pharmacokinetics of buprenorphine.
• Process Chemistry & Impurity Profiling: Essential for identifying, synthesizing, and controlling potential genotoxic impurities (PGIs) and other process-related substances in API manufacturing.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new opioid receptor ligands with modified pharmacological profiles.

Basic Information

Product Name	3-o-(tert-Butyldimethylsilyloxy)-6-o-Desmethyl Buprenorphine
CAS No.	130668-49-4
Molecular Formula	C32H49NO4Si
Molecular Weight	539.83 g/mol
Synonyms	6-Desmethyl Buprenorphine 3-TBDMS Ether; Buprenorphine Impurity F (TBDMS derivative); 3-(tert-Butyldimethylsilyloxy)-6-desmethyl Buprenorphine; NorBuprenorphine 3-TBDMS Ether; 21-Cyclopropyl-7-[(1R,5S)-3-hydroxy-3,3-dimethylbutan-2-yl]-6,14-ethano-6,7,8,14-tetrahydrooripavine 3-(tert-butyldimethylsilyl) ether; 3-O-TBDMS-6-O-desmethyl Buprenorphine; Buprenorphine Related Compound F (TBDMS)
EINECS	Contact for details

Quality Control

Our 3-o-(tert-Butyldimethylsilyloxy)-6-o-Desmethyl Buprenorphine is manufactured under strict quality systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.