Description

8-Deschloro-8-Bromo-n-Methyl Desloratadine is a key pharmaceutical intermediate and a structurally modified derivative of desloratadine, a well-known non-sedating antihistamine. This compound is of significant interest for research and development in the synthesis of novel active pharmaceutical ingredients (APIs) and for exploring new therapeutic pathways. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in advanced medicinal chemistry and process optimization.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel antihistamine compounds and related API derivatives.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of desloratadine analogs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for pharmacological and biochemical studies.
• Custom Synthesis: Starting material for the contract manufacturing of specialized fine chemicals and bespoke molecular targets.

Basic Information

Product Name	8-Deschloro-8-Bromo-n-Methyl Desloratadine
CAS No.	130642-57-8
Molecular Formula	C20H21BrN2
Molecular Weight	369.30 g/mol
Synonyms	8-Bromo-8-deschlorodesloratadine; 8-Bromo-N-methyl-19-(4-piperidinylidene)-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-5-amine; 8-Bromo-19-(4-piperidinylidene)-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-5-amine, N-methyl-; Desloratadine Impurity; Desloratadine Related Compound B (bromo analog)
EINECS	Contact for details

Quality Control

Our 8-Deschloro-8-Bromo-n-Methyl Desloratadine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.