Description

Loratadine Ketone is a key pharmaceutical intermediate in the synthesis of the widely used non-sedating antihistamine, Loratadine. Its precise chemical structure and high purity are critical for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). This compound is essential for manufacturers in the pharmaceutical industry engaged in the production of allergy and antihistamine medications. Consistent quality and reliable supply of this intermediate are fundamental to maintaining robust and compliant drug manufacturing processes.

Application

• Primary Intermediate for the synthesis of Loratadine API.
• Pharmaceutical Research & Development (R&D) for novel antihistamine compounds.
• Generic Drug Manufacturing for cost-effective production of allergy medications.
• Contract Manufacturing Organizations (CMOs) specializing in API production.
• Reference Standard for quality control and analytical method development.
• Process Chemistry optimization and scale-up studies.

Basic Information

Product Name	Loratadine Ketone
CAS No.	130642-50-1
Molecular Formula	C20H19ClN2O2
Molecular Weight	354.83 g/mol
Synonyms	8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-5-one; Loratadine Impurity C; Desloratadine Ketone; Norloratadine Ketone; 11-(1-Methyl-4-piperidinylidene)-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-5-one; Loratadine Related Compound C; SC-37226 Ketone
EINECS	Contact for details

Quality Control

Our Loratadine Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing all specified parameters. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.