Description

1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclopropanemethanol is a high-value organosilicon-protected cyclopropane derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its primary value lies in providing a robust, orthogonal protecting group for the hydroxymethyl functionality, enabling complex multi-step reactions with high selectivity and yield. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of proprietary drug candidates, especially those containing cyclopropane rings for conformational restriction.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with enhanced biological activity and environmental profile.
• Asymmetric Catalysis: Used in the preparation of chiral ligands and auxiliaries for stereoselective transformations.
• Material Science Research: Precursor for specialty monomers and polymers with unique thermal or mechanical properties derived from the strained cyclopropane structure.
• Natural Product Synthesis: Intermediate in the total synthesis of complex natural products that incorporate cyclopropane motifs.
• Process Chemistry Development: Enables scalable, efficient routes to target molecules in kilo lab and pilot plant settings due to the stability of the tert-butyldimethylsilyl (TBDMS) protecting group.

Basic Information

Product Name	1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclopropanemethanol
CAS No.	130632-73-4
Molecular Formula	C11H24O2Si
Molecular Weight	216.40 g/mol
Synonyms	Cyclopropanemethanol, 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 1-((tert-Butyldimethylsilyl)oxy)cyclopropanemethanol; (1-((tert-Butyldimethylsilyl)oxy)cyclopropyl)methanol; TBDMS-protected cyclopropanemethanol; 1-(tert-Butyldimethylsiloxy)cyclopropanemethanol; (1-Hydroxymethylcyclopropyloxy)-tert-butyldimethylsilane; 1-[(tert-Butyldimethylsilyl)oxy]cyclopropylmethanol
EINECS	Contact for details

Quality Control

Our 1-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Cyclopropanemethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee traceability, consistency, and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.